Assay Detail
ADMET
CHEMBL911385
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Cytotoxicity against androgen sensitive human LNCaP cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.47 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 7.52 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.51 |
| CHEMBL28941 | — | — | 1 | 7.25 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 6.82 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 4.94 |
| CHEMBL376657 | DYSOSMAROL | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL61 | PODOFILOX | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL28941 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL376657 | DYSOSMAROL | IC50 | = | 16000.0 | nM | 4.80 |