Assay Detail
Binding
CHEMBL911395
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Inhibition of human recombinant cathepsin K
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.46 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386506 | — | — | 1 | 11.00 |
| CHEMBL374890 | — | — | 1 | 10.96 |
| CHEMBL414530 | — | — | 1 | 10.96 |
| CHEMBL449096 | — | — | 1 | 10.89 |
| CHEMBL218024 | — | — | 1 | 10.66 |
| CHEMBL220760 | — | — | 1 | 10.60 |
| CHEMBL436303 | — | — | 1 | 10.51 |
| CHEMBL219536 | — | — | 1 | 10.33 |
| CHEMBL374695 | — | — | 1 | 9.52 |
| CHEMBL217930 | — | — | 1 | 9.12 |
| CHEMBL363847 | — | — | 1 | 8.22 |
| CHEMBL221804 | — | — | 1 | 6.92 |
| CHEMBL221591 | — | — | 1 | 6.77 |
| CHEMBL218522 | — | — | 1 | 6.00 |
| CHEMBL220496 | — | — | 1 | - |
| CHEMBL385632 | — | — | 1 | - |
| CHEMBL221707 | — | — | 1 | - |
| CHEMBL218007 | — | — | 1 | - |
| CHEMBL218685 | — | — | 1 | - |
| CHEMBL218684 | — | — | 1 | - |
| CHEMBL384685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386506 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL374890 | — | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL414530 | — | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL449096 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL218024 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL220760 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL436303 | — | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL219536 | — | IC50 | = | 0.047 | nM | 10.33 |
| CHEMBL374695 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL217930 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL363847 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL221804 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL221591 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL218522 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL220496 | — | IC50 | < | 0.003 | nM | - |
| CHEMBL385632 | — | IC50 | = | 0.009 | nM | - |
| CHEMBL221707 | — | IC50 | < | 0.003 | nM | - |
| CHEMBL218007 | — | IC50 | = | 0.003 | nM | - |
| CHEMBL218685 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL218684 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL384685 | — | IC50 | = | 0.003 | nM | - |