Assay Detail
Binding
CHEMBL911397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cathepsin S
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.81 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386506 | — | — | 1 | 9.89 |
| CHEMBL385632 | — | — | 1 | 9.64 |
| CHEMBL219536 | — | — | 1 | 9.32 |
| CHEMBL384685 | — | — | 1 | 9.29 |
| CHEMBL218024 | — | — | 1 | 9.15 |
| CHEMBL218007 | — | — | 1 | 9.05 |
| CHEMBL221707 | — | — | 1 | 9.05 |
| CHEMBL220496 | — | — | 1 | 8.80 |
| CHEMBL414530 | — | — | 1 | 8.74 |
| CHEMBL217930 | — | — | 1 | 8.64 |
| CHEMBL374890 | — | — | 1 | 8.60 |
| CHEMBL436303 | — | — | 1 | 8.59 |
| CHEMBL220760 | — | — | 1 | 8.51 |
| CHEMBL449096 | — | — | 1 | 8.00 |
| CHEMBL363847 | — | — | 1 | 6.82 |
| CHEMBL374695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386506 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL385632 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL219536 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL384685 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL218024 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL218007 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL221707 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL220496 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL414530 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL217930 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL374890 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL436303 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL220760 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL449096 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL363847 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL374695 | — | IC50 | > | 10.0 | nM | - |