Assay Detail
Functional
CHEMBL911785
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Antiproliferative activity against human CEM cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.44 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL217472 | — | — | 1 | 8.35 |
| CHEMBL387263 | — | — | 1 | 8.23 |
| CHEMBL410661 | — | — | 1 | 8.03 |
| CHEMBL217301 | — | — | 1 | 8.02 |
| CHEMBL217797 | — | — | 1 | 7.82 |
| CHEMBL217297 | — | — | 1 | 7.82 |
| CHEMBL426514 | — | — | 1 | 7.80 |
| CHEMBL217256 | — | — | 1 | 7.80 |
| CHEMBL218188 | — | — | 1 | 7.72 |
| CHEMBL217134 | — | — | 1 | 7.70 |
| CHEMBL386381 | — | — | 1 | 7.16 |
| CHEMBL218241 | — | — | 1 | 7.07 |
| CHEMBL385640 | — | — | 1 | 7.00 |
| CHEMBL385531 | — | — | 1 | 6.96 |
| CHEMBL384779 | — | — | 1 | 6.82 |
| CHEMBL217075 | — | — | 1 | 6.57 |
| CHEMBL385766 | — | — | 1 | 6.57 |
| CHEMBL217838 | — | — | 1 | 6.54 |
| CHEMBL384313 | — | — | 1 | 6.08 |
| CHEMBL409465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL217472 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL387263 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL410661 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL217301 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL217797 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL217297 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL426514 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL217256 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL218188 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL217134 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL386381 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL218241 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL385640 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL385531 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL384779 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL217075 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL385766 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL217838 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL384313 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL409465 | — | IC50 | > | 10000.0 | nM | - |