Assay Detail
Functional
CHEMBL911931
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Antiproliferative activity against NCI60 cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.13 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | — | 1 | 7.70 |
| CHEMBL221540 | — | — | 1 | 7.16 |
| CHEMBL221697 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL221540 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL221697 | — | IC50 | = | 300.0 | nM | 6.52 |