Assay Detail
Functional
CHEMBL911962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CGRP-induced cAMP production in E10 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | E10 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.76 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375533 | — | — | 1 | 7.62 |
| CHEMBL374064 | — | — | 1 | 7.41 |
| CHEMBL374251 | — | — | 1 | 7.30 |
| CHEMBL220146 | — | — | 1 | 7.30 |
| CHEMBL220715 | — | — | 1 | 7.27 |
| CHEMBL220101 | — | — | 1 | 7.21 |
| CHEMBL375224 | — | — | 1 | 7.19 |
| CHEMBL223756 | — | — | 1 | 7.19 |
| CHEMBL223156 | — | — | 1 | 7.11 |
| CHEMBL376292 | — | — | 1 | 6.96 |
| CHEMBL221009 | — | — | 1 | 6.92 |
| CHEMBL374666 | — | — | 1 | 6.75 |
| CHEMBL219782 | — | — | 1 | 6.46 |
| CHEMBL219721 | — | — | 1 | 6.37 |
| CHEMBL385322 | — | — | 1 | 6.28 |
| CHEMBL223805 | — | — | 1 | 6.16 |
| CHEMBL221160 | — | — | 1 | 5.85 |
| CHEMBL220336 | — | — | 1 | 5.54 |
| CHEMBL376263 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375533 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL374064 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL374251 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL220146 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL220715 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL220101 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL375224 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL223756 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL223156 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL376292 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL221009 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL374666 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL219782 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL219721 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL385322 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL223805 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL221160 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL220336 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL376263 | — | IC50 | = | 3300.0 | nM | 5.48 |