Compound Detail
CHEMBL374251
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CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccc(C(F)(F)F)n4)c4ccccc43)cc1C2
Basic Information
| ChEMBL ID | CHEMBL374251 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CBYMKRJSUMRSHK-RUZDIDTESA-N |
1
Targets
2
Activities
2
Assay Types
3
PK Parameters
2
Publications
0
Known Names
Molecular Properties
551.5
MW (Da)
2.26
ALogP
8
HBA
2
HBD
131.2
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.3
Ki 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcitonin gene-related peptide type 1 receptor CHEMBL3798 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Calcitonin gene-related peptide type 1 receptor CHEMBL3798 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 7.5 | mL.min-1.kg-1 | Rattus norvegicus |
| F | - | % | Rattus norvegicus |
| T1/2 | 2.8 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcitonin gene-related peptide type 1 receptor | Ki | = | 10.0 | nM | 8.0 | Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 ... | 17027263 |
| Calcitonin gene-related peptide type 1 receptor | IC50 | = | 50.0 | nM | 7.3 | Inhibition of CGRP-induced cAMP production in E10 cells | 17027263 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17027263 | 10.1016/j.bmcl.2006.09.045 | Rattus norvegicus | 4 |
| 17027263 | 10.1016/j.bmcl.2006.09.045 | Calcitonin gene-related peptide type 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine