Assay Detail
Binding
CHEMBL911979
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Inhibition of GST-MLK3 expressed in baculovirus
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.96 | 7.92 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386636 | — | — | 1 | 7.92 |
| CHEMBL416056 | — | — | 1 | 7.89 |
| CHEMBL374581 | — | — | 1 | 7.66 |
| CHEMBL221536 | — | — | 1 | 7.58 |
| CHEMBL357490 | — | — | 1 | 7.40 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 7.31 |
| CHEMBL126545 | — | — | 1 | 7.24 |
| CHEMBL148471 | — | — | 1 | 7.06 |
| CHEMBL384914 | — | — | 1 | 6.96 |
| CHEMBL220497 | — | — | 1 | 6.80 |
| CHEMBL220799 | — | — | 1 | 6.77 |
| CHEMBL426719 | — | — | 1 | 6.57 |
| CHEMBL375220 | — | — | 1 | 6.56 |
| CHEMBL332575 | — | — | 1 | 6.52 |
| CHEMBL375085 | — | — | 1 | 6.14 |
| CHEMBL374639 | — | — | 1 | 5.96 |
| CHEMBL17031 | — | — | 1 | 5.92 |
| CHEMBL374722 | — | — | 1 | - |
| CHEMBL220961 | — | — | 1 | - |
| CHEMBL374353 | — | — | 1 | - |
| CHEMBL201931 | — | — | 1 | - |
| CHEMBL202426 | — | — | 1 | - |
| CHEMBL278969 | — | — | 1 | - |
| CHEMBL219159 | — | — | 1 | - |
| CHEMBL375093 | — | — | 1 | - |
| CHEMBL222068 | — | — | 1 | - |
| CHEMBL375139 | — | — | 1 | - |
| CHEMBL438054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386636 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL416056 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL374581 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL221536 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL357490 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL126545 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL148471 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL384914 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL220497 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL220799 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL426719 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL375220 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL332575 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL375085 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL374639 | — | IC50 | = | 1106.0 | nM | 5.96 |
| CHEMBL17031 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL374722 | — | Activity | - | — | - | |
| CHEMBL220961 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL374353 | — | Activity | - | — | - | |
| CHEMBL201931 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL202426 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL278969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL219159 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL375093 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL222068 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375139 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL438054 | — | IC50 | > | 300.0 | nM | - |