Assay Detail
Functional
CHEMBL911996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MKK4 phosphorylation in MLK1 transfected CHO cells after 1 hr
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase 9 (CHEMBL2872) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.81 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386636 | — | — | 1 | 7.05 |
| CHEMBL374581 | — | — | 1 | 6.56 |
| CHEMBL416056 | — | — | 1 | - |
| CHEMBL222068 | — | — | 1 | - |
| CHEMBL220961 | — | — | 1 | - |
| CHEMBL374639 | — | — | 1 | - |
| CHEMBL438054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386636 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL374581 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL416056 | — | IC50 | - | — | - | |
| CHEMBL222068 | — | IC50 | - | — | - | |
| CHEMBL220961 | — | IC50 | - | — | - | |
| CHEMBL374639 | — | IC50 | - | — | - | |
| CHEMBL438054 | — | IC50 | - | — | - |