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Assay Detail

CHEMBL912135

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Binding
Binding affinity to LXRalpha by radioligand displacement assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxysterols receptor LXR-alpha (CHEMBL2808) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.
Panday N, Benz J, Blum-Kaelin D, Bourgeaux V, Dehmlow H, Hartman P, Kuhn B, Ratni H, Warot X, Wright MB.
Bioorg Med Chem Lett (2006) 16 : 5231 -5237
PubMed 16876993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 6.72 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL384246 — — 1 9.00
CHEMBL215108 — — 1 8.70
CHEMBL215663 — — 1 8.52
CHEMBL215789 — — 1 8.30
CHEMBL383944 — — 1 8.22
CHEMBL386530 — — 1 8.22
CHEMBL214867 — — 1 8.22
CHEMBL215042 — — 1 7.89
CHEMBL215036 — — 1 7.70
CHEMBL62136 T091317 — 1 7.52
CHEMBL386603 — — 1 7.52
CHEMBL383959 — — 1 7.30
CHEMBL215904 — — 1 7.30
CHEMBL263089 — — 1 7.30
CHEMBL384298 — — 1 7.30
CHEMBL269442 — — 1 7.22
CHEMBL215130 — — 1 7.22
CHEMBL383945 — — 1 7.22
CHEMBL215167 — — 1 7.22
CHEMBL214777 — — 1 7.16
CHEMBL214546 — — 1 7.00
CHEMBL386260 — — 1 7.00
CHEMBL214687 — — 1 7.00
CHEMBL215585 — — 1 6.92
CHEMBL214741 — — 1 6.70
CHEMBL214948 — — 1 6.70
CHEMBL215647 — — 1 6.70
CHEMBL215959 — — 1 6.70
CHEMBL215598 — — 1 6.40
CHEMBL448111 — — 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL384246 — IC50 = 1.0 nM 9.00
CHEMBL215108 — IC50 = 2.0 nM 8.70
CHEMBL215663 — IC50 = 3.0 nM 8.52
CHEMBL215789 — IC50 = 5.0 nM 8.30
CHEMBL383944 — IC50 = 6.0 nM 8.22
CHEMBL386530 — IC50 = 6.0 nM 8.22
CHEMBL214867 — IC50 = 6.0 nM 8.22
CHEMBL215042 — IC50 = 13.0 nM 7.89
CHEMBL215036 — IC50 = 20.0 nM 7.70
CHEMBL62136 T091317 IC50 = 30.0 nM 7.52
CHEMBL386603 — IC50 = 30.0 nM 7.52
CHEMBL263089 — IC50 = 50.0 nM 7.30
CHEMBL384298 — IC50 = 50.0 nM 7.30
CHEMBL215904 — IC50 = 50.0 nM 7.30
CHEMBL383959 — IC50 = 50.0 nM 7.30
CHEMBL269442 — IC50 = 60.0 nM 7.22
CHEMBL215167 — IC50 = 60.0 nM 7.22
CHEMBL383945 — IC50 = 60.0 nM 7.22
CHEMBL215130 — IC50 = 60.0 nM 7.22
CHEMBL214777 — IC50 = 70.0 nM 7.16
CHEMBL214546 — IC50 = 100.0 nM 7.00
CHEMBL386260 — IC50 = 100.0 nM 7.00
CHEMBL214687 — IC50 = 100.0 nM 7.00
CHEMBL215585 — IC50 = 120.0 nM 6.92
CHEMBL214741 — IC50 = 200.0 nM 6.70
CHEMBL215959 — IC50 = 200.0 nM 6.70
CHEMBL214948 — IC50 = 200.0 nM 6.70
CHEMBL215647 — IC50 = 200.0 nM 6.70
CHEMBL215598 — IC50 = 400.0 nM 6.40
CHEMBL448111 — IC50 = 500.0 nM 6.30
CHEMBL214832 — IC50 = 500.0 nM 6.30
CHEMBL386174 — IC50 = 600.0 nM 6.22
CHEMBL385052 — IC50 = 600.0 nM 6.22
CHEMBL214942 — IC50 = 700.0 nM 6.16
CHEMBL215129 — IC50 = 900.0 nM 6.05
CHEMBL385411 — IC50 = 1100.0 nM 5.96
CHEMBL385489 — IC50 = 1300.0 nM 5.89
CHEMBL214727 — IC50 = 1500.0 nM 5.82
CHEMBL214275 — IC50 = 1700.0 nM 5.77
CHEMBL409212 — IC50 = 2200.0 nM 5.66
CHEMBL216055 — IC50 = 2700.0 nM 5.57
CHEMBL215327 — IC50 = 5200.0 nM 5.28
CHEMBL385544 — IC50 = 5400.0 nM 5.27
CHEMBL215154 — IC50 = 11200.0 nM 4.95
CHEMBL214915 — IC50 = 12000.0 nM 4.92
CHEMBL215775 — IC50 = 13800.0 nM 4.86
CHEMBL385546 — IC50 = 18000.0 nM 4.75
CHEMBL215445 — IC50 = 61000.0 nM 4.21