Compound Detail
CHEMBL216055
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL216055 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWZYPDLJUKHKNM-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.3
MW (Da)
4.42
ALogP
3
HBA
1
HBD
36.4
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.64
IC50 2 meas. best 5.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta CHEMBL4093 | EC50 | 5.64 | 5.64 | 2300.0 | 1 |
| Oxysterols receptor LXR-beta CHEMBL4093 | IC50 | 5.63 | 5.63 | 2320.0 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | EC50 | 5.37 | 5.37 | 4300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta | EC50 | = | 2300.0 | nM | 5.64 | Transactivation of LXRbeta by luciferase reporter gene assay | 16876993 |
| Oxysterols receptor LXR-beta | IC50 | = | 2320.0 | nM | 5.63 | Binding affinity to LXRbeta by radioligand displacement assay | 16876993 |
| Oxysterols receptor LXR-alpha | IC50 | = | 2700.0 | nM | 5.57 | Binding affinity to LXRalpha by radioligand displacement assay | 16876993 |
| Oxysterols receptor LXR-alpha | EC50 | = | 4300.0 | nM | 5.37 | Transactivation of LXRalpha by luciferase reporter gene assay | 16876993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16876993 | 10.1016/j.bmcl.2006.06.081 | Oxysterols receptor LXR-alpha | 3 |
| 16876993 | 10.1016/j.bmcl.2006.06.081 | Oxysterols receptor LXR-beta | 3 |
Data from ChEMBL 36 via Core Engine