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Assay Detail

CHEMBL912145

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Transactivation of LXRalpha by luciferase reporter gene assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxysterols receptor LXR-alpha (CHEMBL2808) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.
Panday N, Benz J, Blum-Kaelin D, Bourgeaux V, Dehmlow H, Hartman P, Kuhn B, Ratni H, Warot X, Wright MB.
Bioorg Med Chem Lett (2006) 16 : 5231 -5237
PubMed 16876993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 48 6.01 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL383945 — — 1 7.05
CHEMBL384246 — — 1 7.00
CHEMBL383944 — — 1 7.00
CHEMBL215904 — — 1 7.00
CHEMBL215663 — — 1 6.70
CHEMBL215789 — — 1 6.70
CHEMBL214867 — — 1 6.70
CHEMBL384298 — — 1 6.70
CHEMBL62136 T091317 — 1 6.60
CHEMBL263089 — — 1 6.52
CHEMBL215108 — — 1 6.52
CHEMBL214741 — — 1 6.40
CHEMBL214948 — — 1 6.40
CHEMBL215167 — — 1 6.30
CHEMBL214832 — — 1 6.30
CHEMBL215036 — — 1 6.30
CHEMBL214727 — — 1 6.16
CHEMBL215042 — — 1 6.16
CHEMBL215130 — — 1 6.16
CHEMBL386530 — — 1 6.10
CHEMBL215129 — — 1 6.10
CHEMBL214777 — — 1 6.05
CHEMBL215598 — — 1 6.05
CHEMBL386603 — — 1 6.00
CHEMBL215585 — — 1 6.00
CHEMBL448111 — — 1 6.00
CHEMBL383959 — — 1 5.96
CHEMBL215959 — — 1 5.96
CHEMBL214687 — — 1 5.85
CHEMBL385489 — — 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL383945 — EC50 = 90.0 nM 7.05
CHEMBL384246 — EC50 = 100.0 nM 7.00
CHEMBL215904 — EC50 = 100.0 nM 7.00
CHEMBL383944 — EC50 = 100.0 nM 7.00
CHEMBL215663 — EC50 = 200.0 nM 6.70
CHEMBL215789 — EC50 = 200.0 nM 6.70
CHEMBL214867 — EC50 = 200.0 nM 6.70
CHEMBL384298 — EC50 = 200.0 nM 6.70
CHEMBL62136 T091317 EC50 = 250.0 nM 6.60
CHEMBL263089 — EC50 = 300.0 nM 6.52
CHEMBL215108 — EC50 = 300.0 nM 6.52
CHEMBL214741 — EC50 = 400.0 nM 6.40
CHEMBL214948 — EC50 = 400.0 nM 6.40
CHEMBL214832 — EC50 = 500.0 nM 6.30
CHEMBL215167 — EC50 = 500.0 nM 6.30
CHEMBL215036 — EC50 = 500.0 nM 6.30
CHEMBL214727 — EC50 = 700.0 nM 6.16
CHEMBL215042 — EC50 = 700.0 nM 6.16
CHEMBL215130 — EC50 = 700.0 nM 6.16
CHEMBL386530 — EC50 = 800.0 nM 6.10
CHEMBL215129 — EC50 = 800.0 nM 6.10
CHEMBL214777 — EC50 = 900.0 nM 6.05
CHEMBL215598 — EC50 = 900.0 nM 6.05
CHEMBL448111 — EC50 = 1000.0 nM 6.00
CHEMBL215585 — EC50 = 1000.0 nM 6.00
CHEMBL386603 — EC50 = 1000.0 nM 6.00
CHEMBL383959 — EC50 = 1100.0 nM 5.96
CHEMBL215959 — EC50 = 1100.0 nM 5.96
CHEMBL214687 — EC50 = 1400.0 nM 5.85
CHEMBL385489 — EC50 = 1500.0 nM 5.82
CHEMBL385411 — EC50 = 1900.0 nM 5.72
CHEMBL215647 — EC50 = 1900.0 nM 5.72
CHEMBL214275 — EC50 = 2100.0 nM 5.68
CHEMBL409212 — EC50 = 2200.0 nM 5.66
CHEMBL385052 — EC50 = 2200.0 nM 5.66
CHEMBL214942 — EC50 = 2300.0 nM 5.64
CHEMBL386174 — EC50 = 3300.0 nM 5.48
CHEMBL386260 — EC50 = 3700.0 nM 5.43
CHEMBL216055 — EC50 = 4300.0 nM 5.37
CHEMBL269442 — EC50 = 4500.0 nM 5.35
CHEMBL214546 — EC50 = 5500.0 nM 5.26
CHEMBL385544 — EC50 = 8500.0 nM 5.07
CHEMBL215327 — EC50 = 9400.0 nM 5.03
CHEMBL215775 — EC50 = 9300.0 nM 5.03
CHEMBL215445 — EC50 = 10000.0 nM 5.00
CHEMBL215154 — EC50 = 10900.0 nM 4.96
CHEMBL214915 — EC50 > 40000.0 nM -
CHEMBL385546 — EC50 > 40000.0 nM -