Assay Detail
Functional
CHEMBL912404
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Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.43 | 8.55 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216258 | — | — | 1 | 8.55 |
| CHEMBL441618 | — | — | 1 | 7.22 |
| CHEMBL216439 | — | — | 1 | 6.52 |
| CHEMBL216446 | — | — | 1 | - |
| CHEMBL386491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216258 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL441618 | — | Ki | = | 60.4 | nM | 7.22 |
| CHEMBL216439 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL216446 | — | Activity | - | — | - | |
| CHEMBL386491 | — | Activity | - | — | - |