Assay Detail
Binding
CHEMBL912437
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Inhibition of CDK2/Cyclin E in presence of 100 uM ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.32 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215205 | — | — | 1 | 4.70 |
| CHEMBL387068 | — | — | 1 | 4.66 |
| CHEMBL214475 | — | — | 1 | 4.29 |
| CHEMBL217734 | — | — | 1 | 4.17 |
| CHEMBL428639 | — | — | 1 | 4.11 |
| CHEMBL384625 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215205 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL387068 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL214475 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL217734 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL428639 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL384625 | — | IC50 | = | 100000.0 | nM | 4.00 |