Assay Detail
Functional
CHEMBL912470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against alternating current-induced arrhythmia in guinea pig left atrium
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel quinolizidinyl derivatives as antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.56 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385527 | — | — | 1 | 6.34 |
| CHEMBL373373 | — | — | 1 | 6.33 |
| CHEMBL219516 | — | — | 1 | 6.01 |
| CHEMBL218302 | — | — | 1 | 5.90 |
| CHEMBL218250 | — | — | 1 | 5.32 |
| CHEMBL218853 | — | — | 1 | 5.24 |
| CHEMBL218303 | — | — | 1 | 5.17 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.99 |
| CHEMBL414124 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385527 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL373373 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL219516 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL218302 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL218250 | — | EC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL218853 | — | EC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL218303 | — | EC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL1294 | QUINIDINE | EC50 | = | 10260.0 | nM | 4.99 |
| CHEMBL414124 | — | EC50 | = | 19870.0 | nM | 4.70 |