Assay Detail
Binding
CHEMBL912582
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Inhibition of MAO-B in bovine brain mitochondria fluorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Subcellular | Mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.80 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424940 | — | — | 1 | 9.00 |
| CHEMBL218059 | — | — | 1 | 8.22 |
| CHEMBL221293 | — | — | 1 | 8.05 |
| CHEMBL375966 | — | — | 1 | 8.00 |
| CHEMBL385397 | — | — | 1 | 7.52 |
| CHEMBL218324 | — | — | 1 | 7.39 |
| CHEMBL375616 | — | — | 1 | 7.00 |
| CHEMBL221593 | — | — | 1 | 6.35 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.00 |
| CHEMBL218323 | — | — | 1 | 5.22 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 4.82 |
| CHEMBL221629 | — | — | 1 | 4.00 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424940 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL218059 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL221293 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL375966 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL385397 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL218324 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL375616 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL221593 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL972 | SELEGILINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL218323 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL221629 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 10000000.0 | nM | - |