Assay Detail
Binding
CHEMBL912602
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Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.40 | 8.74 |
| Log Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301707 | — | — | 1 | 8.74 |
| CHEMBL220515 | — | — | 1 | 8.35 |
| CHEMBL220781 | — | — | 1 | 8.05 |
| CHEMBL386005 | — | — | 1 | 7.97 |
| CHEMBL222896 | — | — | 1 | 7.76 |
| CHEMBL220221 | — | — | 1 | 7.76 |
| CHEMBL99142 | — | — | 1 | 7.68 |
| CHEMBL220717 | — | — | 1 | 7.08 |
| CHEMBL223289 | — | — | 1 | 7.04 |
| CHEMBL219719 | — | — | 1 | 6.22 |
| CHEMBL219718 | — | — | 1 | 4.72 |
| CHEMBL223842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301707 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL220515 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL220781 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL386005 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL222896 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL220221 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL99142 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL220717 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL223289 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL219719 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL219718 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL223842 | — | Log Ki | - | — | - |