Assay Detail
Functional
CHEMBL912968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.69 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.85 |
| CHEMBL47426 | — | — | 1 | 5.82 |
| CHEMBL217041 | — | — | 1 | 5.80 |
| CHEMBL386803 | — | — | 1 | 5.77 |
| CHEMBL216956 | — | — | 1 | 5.75 |
| CHEMBL424885 | — | — | 1 | 5.68 |
| CHEMBL217139 | — | — | 1 | 5.68 |
| CHEMBL216433 | — | — | 1 | 5.62 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.50 |
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | — | 1 | 5.46 |
| CHEMBL217336 | — | — | 1 | - |
| CHEMBL217824 | — | — | 1 | - |
| CHEMBL385699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL47426 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL217041 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL386803 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL216956 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL424885 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL217139 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL216433 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL107 | COLCHICINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL217336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217824 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL385699 | — | IC50 | > | 10000.0 | nM | - |