Assay Detail
Functional
CHEMBL913008
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Activity at adrenergic alpha 1B receptor assessed as antagonsim of phenylephrine-induced contraction of Sprague-Dawley rat spleen
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.63 | 9.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217469 | — | — | 1 | 9.69 |
| CHEMBL215421 | — | — | 1 | 9.17 |
| CHEMBL383938 | — | — | 1 | 8.35 |
| CHEMBL25554 | — | — | 1 | 8.21 |
| CHEMBL215151 | — | — | 1 | 8.12 |
| CHEMBL439346 | — | — | 1 | 7.83 |
| CHEMBL214986 | — | — | 1 | 7.64 |
| CHEMBL214762 | — | — | 1 | 6.88 |
| CHEMBL214694 | — | — | 1 | 6.87 |
| CHEMBL215188 | — | — | 1 | 5.61 |
| CHEMBL218079 | — | — | 1 | 5.58 |
| CHEMBL385371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217469 | — | Kd | = | 0.2042 | nM | 9.69 |
| CHEMBL215421 | — | Kd | = | 0.6761 | nM | 9.17 |
| CHEMBL383938 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL25554 | — | Kd | = | 6.166 | nM | 8.21 |
| CHEMBL215151 | — | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL439346 | — | Kd | = | 14.79 | nM | 7.83 |
| CHEMBL214986 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL214762 | — | Kd | = | 131.83 | nM | 6.88 |
| CHEMBL214694 | — | Kd | = | 134.9 | nM | 6.87 |
| CHEMBL215188 | — | Kd | = | 2454.71 | nM | 5.61 |
| CHEMBL218079 | — | Kd | = | 2630.27 | nM | 5.58 |
| CHEMBL385371 | — | Kd | > | 10000.0 | nM | - |