Assay Detail
Binding
CHEMBL913121
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Inhibition of mouse recombinant inducible NOS by hemoglobin capture assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.82 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 5.37 |
| CHEMBL427286 | — | — | 1 | 4.80 |
| CHEMBL375949 | — | — | 1 | 4.80 |
| CHEMBL228077 | — | — | 1 | 4.77 |
| CHEMBL227937 | — | — | 1 | 4.75 |
| CHEMBL228212 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | Ki | = | 4280.0 | nM | 5.37 |
| CHEMBL427286 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL375949 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL228077 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL227937 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL228212 | — | Ki | = | 37000.0 | nM | 4.43 |