Assay Detail
Functional
CHEMBL913142
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Antiproliferative effect against mouse L210 cells after 2 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.12 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387717 | — | — | 1 | 9.12 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL227656 | — | — | 1 | 8.36 |
| CHEMBL227027 | — | — | 1 | 7.48 |
| CHEMBL227987 | — | — | 1 | 7.41 |
| CHEMBL190320 | — | — | 1 | 7.24 |
| CHEMBL375259 | — | — | 1 | 7.06 |
| CHEMBL189355 | — | — | 1 | 7.05 |
| CHEMBL223057 | — | — | 1 | 6.82 |
| CHEMBL389223 | — | — | 1 | 6.82 |
| CHEMBL227835 | — | — | 1 | 6.80 |
| CHEMBL371795 | — | — | 1 | 6.46 |
| CHEMBL191073 | — | — | 1 | 5.43 |
| CHEMBL227972 | — | — | 1 | 5.02 |
| CHEMBL227478 | — | — | 1 | - |
| CHEMBL228054 | — | — | 1 | - |
| CHEMBL228167 | — | — | 1 | - |
| CHEMBL364695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387717 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL227656 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL227027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL227987 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL190320 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL375259 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL189355 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL223057 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL389223 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL227835 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL371795 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL191073 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL227972 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL227478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL228054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL228167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364695 | — | IC50 | > | 10000.0 | nM | - |