Assay Detail
Functional
CHEMBL913145
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Antiproliferative effect against human CEM cells after 3 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.31 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387717 | — | — | 1 | 9.28 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL227656 | — | — | 1 | 8.35 |
| CHEMBL227987 | — | — | 1 | 8.11 |
| CHEMBL227027 | — | — | 1 | 8.05 |
| CHEMBL190320 | — | — | 1 | 7.62 |
| CHEMBL189355 | — | — | 1 | 7.13 |
| CHEMBL375259 | — | — | 1 | 7.05 |
| CHEMBL227835 | — | — | 1 | 7.01 |
| CHEMBL389223 | — | — | 1 | 7.00 |
| CHEMBL371795 | — | — | 1 | 6.51 |
| CHEMBL223057 | — | — | 1 | 6.34 |
| CHEMBL191073 | — | — | 1 | 5.77 |
| CHEMBL227972 | — | — | 1 | 5.34 |
| CHEMBL228054 | — | — | 1 | - |
| CHEMBL228167 | — | — | 1 | - |
| CHEMBL227478 | — | — | 1 | - |
| CHEMBL364695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387717 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL227656 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL227987 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL227027 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL190320 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL189355 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL375259 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL227835 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL389223 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL371795 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL223057 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL191073 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL227972 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL228054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL228167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL227478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364695 | — | IC50 | > | 10000.0 | nM | - |