Assay Detail
Functional
CHEMBL913231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human T cell proliferation by mixed lymphocyte reaction
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212964 | — | — | 1 | 8.52 |
| CHEMBL214530 | — | — | 1 | 8.30 |
| CHEMBL385055 | — | — | 1 | 7.77 |
| CHEMBL212900 | — | — | 1 | 7.66 |
| CHEMBL215943 | — | — | 1 | 7.52 |
| CHEMBL215863 | — | — | 1 | 7.36 |
| CHEMBL213831 | — | — | 1 | 7.28 |
| CHEMBL212181 | — | — | 1 | 7.14 |
| CHEMBL385937 | — | — | 1 | 7.06 |
| CHEMBL215813 | — | — | 1 | 6.99 |
| CHEMBL215019 | — | — | 1 | 6.88 |
| CHEMBL215691 | — | — | 1 | 6.82 |
| CHEMBL212128 | — | — | 1 | 6.78 |
| CHEMBL215969 | — | — | 1 | 6.75 |
| CHEMBL427226 | — | — | 1 | 6.64 |
| CHEMBL214556 | — | — | 1 | 6.61 |
| CHEMBL386661 | — | — | 1 | 6.61 |
| CHEMBL215745 | — | — | 1 | 6.59 |
| CHEMBL213428 | — | — | 1 | 6.58 |
| CHEMBL424719 | — | — | 1 | 6.55 |
| CHEMBL213290 | — | — | 1 | 6.45 |
| CHEMBL212953 | — | — | 1 | 6.37 |
| CHEMBL385598 | — | — | 1 | 6.30 |
| CHEMBL386842 | — | — | 1 | 6.26 |
| CHEMBL214495 | — | — | 1 | 6.19 |
| CHEMBL384942 | — | — | 1 | 6.18 |
| CHEMBL212195 | — | — | 1 | 6.07 |
| CHEMBL427233 | — | — | 1 | 5.78 |
| CHEMBL212183 | — | — | 1 | 5.77 |
| CHEMBL215529 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212964 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL214530 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL385055 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL212900 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL215943 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL215863 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL213831 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL212181 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL385937 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL215813 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL215019 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL215691 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL212128 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL215969 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL427226 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL214556 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL386661 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL215745 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL213428 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL424719 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL213290 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL212953 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL385598 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL386842 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL214495 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL384942 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL212195 | — | IC50 | = | 844.0 | nM | 6.07 |
| CHEMBL427233 | — | IC50 | = | 1664.0 | nM | 5.78 |
| CHEMBL212183 | — | IC50 | = | 1695.0 | nM | 5.77 |
| CHEMBL215529 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL385477 | — | IC50 | > | 20000.0 | nM | - |