Assay Detail
Functional
CHEMBL913232
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Inhibition of anti CD3/CD28-induced IL2 secretion in human T cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.96 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215943 | — | — | 1 | 7.68 |
| CHEMBL212964 | — | — | 1 | 7.48 |
| CHEMBL386661 | — | — | 1 | 7.44 |
| CHEMBL214530 | — | — | 1 | 7.18 |
| CHEMBL215019 | — | — | 1 | 7.07 |
| CHEMBL385937 | — | — | 1 | 7.06 |
| CHEMBL385055 | — | — | 1 | 7.05 |
| CHEMBL215813 | — | — | 1 | 6.82 |
| CHEMBL215969 | — | — | 1 | 6.80 |
| CHEMBL212181 | — | — | 1 | 6.75 |
| CHEMBL427226 | — | — | 1 | 6.65 |
| CHEMBL214556 | — | — | 1 | 6.34 |
| CHEMBL215691 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215943 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL212964 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL386661 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL214530 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL215019 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL385937 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL385055 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL215813 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL215969 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL212181 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL427226 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL214556 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL215691 | — | IC50 | = | 745.0 | nM | 6.13 |