Assay Detail
Binding
CHEMBL913368
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Inhibition of p70S6K
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.83 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374453 | GSK-299115A | — | 1 | 6.25 |
| CHEMBL427058 | GSK-466317A | — | 1 | 6.23 |
| CHEMBL218654 | — | — | 1 | 5.96 |
| CHEMBL441702 | GSK-270822A | — | 1 | 5.81 |
| CHEMBL375312 | — | — | 1 | 5.71 |
| CHEMBL384073 | GSK-180736A | — | 1 | 5.54 |
| CHEMBL218720 | GSK-466314A | — | 1 | 5.32 |
| CHEMBL217910 | — | — | 1 | - |
| CHEMBL218719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374453 | GSK-299115A | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL427058 | GSK-466317A | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL218654 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL441702 | GSK-270822A | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL375312 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL384073 | GSK-180736A | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL218720 | GSK-466314A | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL217910 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL218719 | — | IC50 | - | — | - |