Compound Detail
CHEMBL374453
GSK-299115A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL374453 |
| Name | GSK-299115A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHTXWIKPNGROHZ-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
4
PK Parameters
20
Publications
0
Known Names
Molecular Properties
415.3
MW (Da)
4.39
ALogP
3
HBA
3
HBD
86.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Ribosomal protein S6 kinase beta-1 CHEMBL4501 | IC50 | 6.25 | 6.25 | 560.0 | 1 |
| Ribosomal protein S6 kinase alpha-1 CHEMBL2553 | IC50 | 6.21 | 6.21 | 620.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL3711550 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.2 | 4.2 | 63100.0 | 1 |
| G protein-coupled receptor kinase 5 CHEMBL3879830 | IC50 | 4.1 | 4.1 | 79400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 57.0 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 804.28 | nM | Rattus norvegicus |
| F | 1.0 | % | Rattus norvegicus |
| T1/2 | 0.8 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 1 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM | 17201405 |
| Ribosomal protein S6 kinase beta-1 | IC50 | = | 560.0 | nM | 6.25 | Inhibition of p70S6K | 17201405 |
| Ribosomal protein S6 kinase alpha-1 | IC50 | = | 620.0 | nM | 6.21 | Inhibition of RSK1 | 17201405 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of bovine GRK2 S670A mutant assessed as decrease in phosphorylation o... | 27362616 |
| Unchecked | IC50 | = | 63100.0 | nM | 4.2 | Inhibition of PKA (unknown origin) using LRRASLG as substrate incubated for 30 m... | 27362616 |
| G protein-coupled receptor kinase 5 | IC50 | = | 79400.0 | nM | 4.1 | Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin aft... | 27362616 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| 17201405 | 10.1021/jm0609014 | Rattus norvegicus | 5 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-4 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase beta-1 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK beta | 2 |
| - | 10.6019/CHEMBL1961873 | Rhodopsin kinase GRK7 | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-beta serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-alpha serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase D2 | 2 |
Data from ChEMBL 36 via Core Engine