Assay Detail
Functional
CHEMBL913586
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Antiproliferative activity against human SK-Mel-5 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.32 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221655 | — | — | 1 | 7.75 |
| CHEMBL220692 | — | — | 1 | 7.54 |
| CHEMBL221654 | — | — | 1 | 7.50 |
| CHEMBL221955 | — | — | 1 | 7.16 |
| CHEMBL376909 | — | — | 1 | 7.00 |
| CHEMBL218097 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221655 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL220692 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL221654 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL221955 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL376909 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL218097 | — | IC50 | = | 102.0 | nM | 6.99 |