Assay Detail
Binding
CHEMBL913626
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Binding affinity to human factor Xa
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.96 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378093 | — | — | 1 | 10.52 |
| CHEMBL373528 | — | — | 1 | 10.40 |
| CHEMBL374306 | — | — | 1 | 9.92 |
| CHEMBL221377 | — | — | 1 | 9.74 |
| CHEMBL221913 | — | — | 1 | 9.74 |
| CHEMBL222079 | — | — | 1 | 9.74 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 9.72 |
| CHEMBL218723 | — | — | 1 | 9.70 |
| CHEMBL218525 | — | — | 1 | 9.46 |
| CHEMBL374305 | — | — | 1 | 9.14 |
| CHEMBL376710 | — | — | 1 | 9.13 |
| CHEMBL221296 | — | — | 1 | 9.12 |
| CHEMBL374187 | — | — | 1 | 9.09 |
| CHEMBL374304 | — | — | 1 | 8.92 |
| CHEMBL221968 | — | — | 1 | 8.70 |
| CHEMBL218659 | — | — | 1 | 8.70 |
| CHEMBL376227 | — | — | 1 | 8.59 |
| CHEMBL385756 | — | — | 1 | 8.57 |
| CHEMBL221092 | — | — | 1 | 7.92 |
| CHEMBL384769 | — | — | 1 | 7.70 |
| CHEMBL221911 | — | — | 1 | 7.33 |
| CHEMBL376622 | — | — | 1 | 7.27 |
| CHEMBL221028 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378093 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL373528 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL374306 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL221377 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL221913 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL222079 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL218723 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL218525 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL374305 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL376710 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL221296 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL374187 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL374304 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL221968 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL218659 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL376227 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL385756 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL221092 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL384769 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL221911 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL376622 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL221028 | — | Ki | = | 88.0 | nM | 7.06 |