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Assay Detail

CHEMBL913786

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against chinese hamster wild-type V79 NTR-ve cells after 18 hrs
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type V79
Confidence 1 — Organism
Curated By Autocuration

Target

V79 (CHEMBL614074)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA.
J Med Chem (2007) 50 : 1197 -1212
PubMed 17326614 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 4.30 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23216 1 4.96
CHEMBL221322 1 4.47
CHEMBL220510 1 4.43
CHEMBL23612 1 4.37
CHEMBL219793 1 4.29
CHEMBL220950 1 4.28
CHEMBL222948 1 4.27
CHEMBL374264 1 4.10
CHEMBL375143 1 4.10
CHEMBL45575 1 4.05
CHEMBL375396 1 4.01
CHEMBL68861 1 -
CHEMBL376038 1 -
CHEMBL220212 1 -
CHEMBL223461 1 -
CHEMBL223755 1 -
CHEMBL223671 1 -
CHEMBL222417 1 -
CHEMBL23330 TRETAZICAR 2.0 1 -
CHEMBL373629 1 -
CHEMBL219981 1 -
CHEMBL220578 1 -
CHEMBL220088 1 -
CHEMBL220524 1 -
CHEMBL306447 1 -
CHEMBL223346 1 -
CHEMBL373624 1 -
CHEMBL282488 1 -
CHEMBL302086 1 -
CHEMBL23355 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23216 IC50 = 11000.0 nM 4.96
CHEMBL221322 IC50 = 34000.0 nM 4.47
CHEMBL220510 IC50 = 37000.0 nM 4.43
CHEMBL23612 IC50 = 43000.0 nM 4.37
CHEMBL219793 IC50 = 51000.0 nM 4.29
CHEMBL220950 IC50 = 52000.0 nM 4.28
CHEMBL222948 IC50 = 54000.0 nM 4.27
CHEMBL374264 IC50 = 80000.0 nM 4.10
CHEMBL375143 IC50 = 80000.0 nM 4.10
CHEMBL45575 IC50 = 89000.0 nM 4.05
CHEMBL375396 IC50 = 97000.0 nM 4.01
CHEMBL376038 IC50 = 348000.0 nM -
CHEMBL441713 IC50 = 174000.0 nM -
CHEMBL68861 IC50 = 201000.0 nM -
CHEMBL223103 IC50 = 6270000.0 nM -
CHEMBL222363 IC50 = 462000.0 nM -
CHEMBL223101 IC50 = 1050000.0 nM -
CHEMBL281563 IC50 = 1160000.0 nM -
CHEMBL223561 IC50 = 438000.0 nM -
CHEMBL426544 IC50 = 273000.0 nM -
CHEMBL67870 IC50 = 312000.0 nM -
CHEMBL374112 IC50 = 750000.0 nM -
CHEMBL281812 IC50 = 490000.0 nM -
CHEMBL426742 IC50 = 148000.0 nM -
CHEMBL427414 IC50 = 275000.0 nM -
CHEMBL223404 IC50 = 328000.0 nM -
CHEMBL304553 IC50 = 4890000.0 nM -
CHEMBL220578 IC50 = 650000.0 nM -
CHEMBL23355 IC50 = 114000.0 nM -
CHEMBL302086 IC50 = 536000.0 nM -
CHEMBL282488 IC50 = 767000.0 nM -
CHEMBL373624 IC50 = 237000.0 nM -
CHEMBL223346 IC50 = 843000.0 nM -
CHEMBL306447 IC50 = 504000.0 nM -
CHEMBL220524 IC50 > 50000.0 nM -
CHEMBL220088 IC50 - -
CHEMBL220212 IC50 = 142000.0 nM -
CHEMBL219981 IC50 = 101000.0 nM -
CHEMBL373629 IC50 = 733000.0 nM -
CHEMBL23330 TRETAZICAR IC50 = 374000.0 nM -
CHEMBL222417 IC50 = 139000.0 nM -
CHEMBL223671 IC50 = 133000.0 nM -
CHEMBL223755 IC50 = 633000.0 nM -
CHEMBL223461 IC50 = 555000.0 nM -