Assay Detail
Functional
CHEMBL913787
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Antiproliferative activity against chinese hamster V79 NTRpuro cells after 18 hrs
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.63 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223671 | — | — | 1 | 6.96 |
| CHEMBL375143 | — | — | 1 | 6.80 |
| CHEMBL23612 | — | — | 1 | 6.75 |
| CHEMBL221322 | — | — | 1 | 6.70 |
| CHEMBL23216 | — | — | 1 | 6.70 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.58 |
| CHEMBL220510 | — | — | 1 | 6.55 |
| CHEMBL219981 | — | — | 1 | 6.54 |
| CHEMBL427414 | — | — | 1 | 6.47 |
| CHEMBL374264 | — | — | 1 | 6.37 |
| CHEMBL302086 | — | — | 1 | 6.31 |
| CHEMBL306447 | — | — | 1 | 6.26 |
| CHEMBL222417 | — | — | 1 | 6.23 |
| CHEMBL220578 | — | — | 1 | 6.06 |
| CHEMBL375396 | — | — | 1 | 6.05 |
| CHEMBL23355 | — | — | 1 | 6.00 |
| CHEMBL223755 | — | — | 1 | 6.00 |
| CHEMBL373629 | — | — | 1 | 6.00 |
| CHEMBL220950 | — | — | 1 | 5.96 |
| CHEMBL219793 | — | — | 1 | 5.87 |
| CHEMBL223461 | — | — | 1 | 5.11 |
| CHEMBL282488 | — | — | 1 | 5.02 |
| CHEMBL281563 | — | — | 1 | 5.00 |
| CHEMBL67870 | — | — | 1 | 4.92 |
| CHEMBL222948 | — | — | 1 | 4.89 |
| CHEMBL223101 | — | — | 1 | 4.89 |
| CHEMBL374112 | — | — | 1 | 4.89 |
| CHEMBL426742 | — | — | 1 | 4.80 |
| CHEMBL373624 | — | — | 1 | 4.80 |
| CHEMBL281812 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223671 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL375143 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL23612 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL221322 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL23216 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL220510 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL219981 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL427414 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL374264 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL302086 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL306447 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL222417 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL220578 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL375396 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL23355 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL373629 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL223755 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL220950 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL219793 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL223461 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL282488 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL281563 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL67870 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL222948 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL223101 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL374112 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL426742 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL373624 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL281812 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL223561 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL220212 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL441713 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL426544 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL222363 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL45575 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL220088 | — | IC50 | - | — | - | |
| CHEMBL304553 | — | IC50 | = | 470000.0 | nM | - |
| CHEMBL223404 | — | IC50 | = | 237000.0 | nM | - |
| CHEMBL223346 | — | IC50 | = | 427000.0 | nM | - |
| CHEMBL220524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL223103 | — | IC50 | = | 1990000.0 | nM | - |
| CHEMBL68861 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL376038 | — | IC50 | = | 105000.0 | nM | - |