Assay Detail
Functional
CHEMBL913795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human wild type Skov3 NTR-ve cells after 18 hrs
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NTR-ve |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 4.16 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23216 | — | — | 1 | 4.52 |
| CHEMBL23612 | — | — | 1 | 4.24 |
| CHEMBL221322 | — | — | 1 | 4.23 |
| CHEMBL222948 | — | — | 1 | 4.17 |
| CHEMBL220510 | — | — | 1 | 4.14 |
| CHEMBL374264 | — | — | 1 | 4.09 |
| CHEMBL375143 | — | — | 1 | 4.07 |
| CHEMBL219981 | — | — | 1 | 4.01 |
| CHEMBL23355 | — | — | 1 | 4.01 |
| CHEMBL223346 | — | — | 1 | - |
| CHEMBL220524 | — | — | 1 | - |
| CHEMBL220578 | — | — | 1 | - |
| CHEMBL373629 | — | — | 1 | - |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
| CHEMBL223461 | — | — | 1 | - |
| CHEMBL220212 | — | — | 1 | - |
| CHEMBL376038 | — | — | 1 | - |
| CHEMBL68861 | — | — | 1 | - |
| CHEMBL223103 | — | — | 1 | - |
| CHEMBL282488 | — | — | 1 | - |
| CHEMBL302086 | — | — | 1 | - |
| CHEMBL223755 | — | — | 1 | - |
| CHEMBL306447 | — | — | 1 | - |
| CHEMBL220088 | — | — | 1 | - |
| CHEMBL222417 | — | — | 1 | - |
| CHEMBL223671 | — | — | 1 | - |
| CHEMBL375396 | — | — | 1 | - |
| CHEMBL426544 | — | — | 1 | - |
| CHEMBL441713 | — | — | 1 | - |
| CHEMBL373624 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23216 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL23612 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL221322 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL222948 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL220510 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL374264 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL375143 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL219981 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL23355 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL376038 | — | IC50 | = | 692000.0 | nM | - |
| CHEMBL223404 | — | IC50 | = | 1040000.0 | nM | - |
| CHEMBL68861 | — | IC50 | = | 383000.0 | nM | - |
| CHEMBL223103 | — | IC50 | = | 8210000.0 | nM | - |
| CHEMBL45575 | — | IC50 | = | 246000.0 | nM | - |
| CHEMBL222363 | — | IC50 | = | 417000.0 | nM | - |
| CHEMBL223101 | — | IC50 | = | 970000.0 | nM | - |
| CHEMBL281563 | — | IC50 | = | 1710000.0 | nM | - |
| CHEMBL223561 | — | IC50 | = | 705000.0 | nM | - |
| CHEMBL304553 | — | IC50 | = | 5720000.0 | nM | - |
| CHEMBL67870 | — | IC50 | = | 1250000.0 | nM | - |
| CHEMBL374112 | — | IC50 | > | 1190000.0 | nM | - |
| CHEMBL219793 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL281812 | — | IC50 | = | 803000.0 | nM | - |
| CHEMBL426742 | — | IC50 | = | 272000.0 | nM | - |
| CHEMBL220950 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL427414 | — | IC50 | = | 283000.0 | nM | - |
| CHEMBL223755 | — | IC50 | = | 286000.0 | nM | - |
| CHEMBL373624 | — | IC50 | = | 379000.0 | nM | - |
| CHEMBL441713 | — | IC50 | = | 474000.0 | nM | - |
| CHEMBL426544 | — | IC50 | = | 438000.0 | nM | - |
| CHEMBL375396 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL223671 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL222417 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL220088 | — | IC50 | = | 1380000.0 | nM | - |
| CHEMBL306447 | — | IC50 | = | 522000.0 | nM | - |
| CHEMBL220212 | — | IC50 | = | 447000.0 | nM | - |
| CHEMBL302086 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL282488 | — | IC50 | = | 980000.0 | nM | - |
| CHEMBL223346 | — | IC50 | = | 2322000.0 | nM | - |
| CHEMBL220524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL220578 | — | IC50 | = | 868000.0 | nM | - |
| CHEMBL373629 | — | IC50 | = | 1110000.0 | nM | - |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 174000.0 | nM | - |
| CHEMBL223461 | — | IC50 | = | 948000.0 | nM | - |