Assay Detail
Functional
CHEMBL913797
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Antiproliferative activity against human Skov3 NTRneo cells after 18 hrs
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.58 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223671 | — | — | 1 | 6.72 |
| CHEMBL220510 | — | — | 1 | 6.64 |
| CHEMBL427414 | — | — | 1 | 6.55 |
| CHEMBL374264 | — | — | 1 | 6.52 |
| CHEMBL219981 | — | — | 1 | 6.51 |
| CHEMBL221322 | — | — | 1 | 6.51 |
| CHEMBL23612 | — | — | 1 | 6.48 |
| CHEMBL375143 | — | — | 1 | 6.40 |
| CHEMBL23216 | — | — | 1 | 6.37 |
| CHEMBL23355 | — | — | 1 | 6.25 |
| CHEMBL223755 | — | — | 1 | 6.21 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.19 |
| CHEMBL306447 | — | — | 1 | 6.11 |
| CHEMBL222417 | — | — | 1 | 6.08 |
| CHEMBL302086 | — | — | 1 | 5.92 |
| CHEMBL375396 | — | — | 1 | 5.84 |
| CHEMBL219793 | — | — | 1 | 5.80 |
| CHEMBL373629 | — | — | 1 | 5.77 |
| CHEMBL220950 | — | — | 1 | 5.64 |
| CHEMBL220578 | — | — | 1 | 5.41 |
| CHEMBL426544 | — | — | 1 | 5.39 |
| CHEMBL223101 | — | — | 1 | 5.38 |
| CHEMBL220088 | — | — | 1 | 5.30 |
| CHEMBL281563 | — | — | 1 | 5.29 |
| CHEMBL67870 | — | — | 1 | 5.23 |
| CHEMBL223461 | — | — | 1 | 5.19 |
| CHEMBL222363 | — | — | 1 | 5.17 |
| CHEMBL222948 | — | — | 1 | 5.12 |
| CHEMBL220212 | — | — | 1 | 5.03 |
| CHEMBL223561 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223671 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL220510 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL427414 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL374264 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL219981 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL221322 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL23612 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL375143 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL23216 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL23355 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL223755 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL306447 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL222417 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL302086 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL375396 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL219793 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL373629 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL220950 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL220578 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL426544 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL223101 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL220088 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL281563 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL67870 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL223461 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL222363 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL222948 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL220212 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL223561 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL281812 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL373624 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL374112 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL282488 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL441713 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL426742 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL45575 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL376038 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL68861 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL223103 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL223346 | — | IC50 | = | 745000.0 | nM | - |
| CHEMBL220524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL304553 | — | IC50 | = | 643000.0 | nM | - |
| CHEMBL223404 | — | IC50 | = | 160000.0 | nM | - |