Assay Detail
Binding
CHEMBL913922
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Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.24 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 7.82 |
| CHEMBL225155 | — | — | 1 | 7.47 |
| CHEMBL184349 | — | — | 1 | 7.35 |
| CHEMBL117723 | — | — | 1 | 7.10 |
| CHEMBL224853 | — | — | 1 | 6.92 |
| CHEMBL334213 | — | — | 1 | 6.85 |
| CHEMBL224549 | — | — | 1 | 6.47 |
| CHEMBL426191 | — | — | 1 | 6.19 |
| CHEMBL224799 | — | — | 1 | 6.10 |
| CHEMBL224571 | — | — | 1 | 5.89 |
| CHEMBL224005 | — | — | 1 | 5.82 |
| CHEMBL425563 | — | — | 1 | 5.80 |
| CHEMBL224599 | — | — | 1 | 5.62 |
| CHEMBL224703 | — | — | 1 | 5.60 |
| CHEMBL389880 | — | — | 1 | 5.57 |
| CHEMBL224800 | — | — | 1 | 5.55 |
| CHEMBL224623 | — | — | 1 | 5.27 |
| CHEMBL225575 | — | — | 1 | 5.00 |
| CHEMBL375488 | — | — | 1 | - |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | - |
| CHEMBL389012 | — | — | 1 | - |
| CHEMBL374614 | — | — | 1 | - |
| CHEMBL224720 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL225155 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL184349 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL117723 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL224853 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL334213 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL224549 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL426191 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL224799 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL224571 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL224005 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL425563 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL224599 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL224703 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL389880 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL224800 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL224623 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL225575 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL375488 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314854 | FINGOLIMOD | IC50 | > | 10000.0 | nM | - |
| CHEMBL389012 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224720 | — | IC50 | > | 10000.0 | nM | - |