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Assay Detail

CHEMBL914037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of microsomal neural aminopeptidase in pig kidney
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Aminopeptidase N (CHEMBL2590)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.
Flipo M, Beghyn T, Charton J, Leroux VA, Deprez BP, Deprez-Poulain RF.
Bioorg Med Chem (2007) 15 : 63 -76
PubMed 17070058 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.06 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220311 1 7.09
CHEMBL425291 1 6.35
CHEMBL220941 1 6.34
CHEMBL116641 1 6.28
CHEMBL220253 1 6.23
CHEMBL223711 1 6.14
CHEMBL220010 1 6.01
CHEMBL220176 1 5.60
CHEMBL29292 UBENIMEX 2.0 1 5.57
CHEMBL442042 1 5.52
CHEMBL390070 1 5.52
CHEMBL376199 1 -
CHEMBL220364 1 -
CHEMBL220996 1 -
CHEMBL113827 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220311 IC50 = 82.0 nM 7.09
CHEMBL425291 IC50 = 443.0 nM 6.35
CHEMBL220941 IC50 = 452.0 nM 6.34
CHEMBL116641 IC50 = 528.0 nM 6.28
CHEMBL220253 IC50 = 590.0 nM 6.23
CHEMBL223711 IC50 = 718.0 nM 6.14
CHEMBL220010 IC50 = 984.0 nM 6.01
CHEMBL220176 IC50 = 2520.0 nM 5.60
CHEMBL29292 UBENIMEX IC50 = 2700.0 nM 5.57
CHEMBL442042 IC50 = 3000.0 nM 5.52
CHEMBL390070 IC50 = 3040.0 nM 5.52
CHEMBL376199 IC50 > 10000.0 nM -
CHEMBL220364 IC50 > 10000.0 nM -
CHEMBL220996 IC50 > 10000.0 nM -
CHEMBL113827 IC50 > 10000.0 nM -