Assay Detail
Functional
CHEMBL914217
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Inhibition of insulin release from rat INS-1E cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | INS-1E |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Virtual screening for novel openers of pancreatic K(ATP) channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.91 | 6.03 |
| EC50 | 2 | 5.69 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.68 |
| CHEMBL112668 | — | — | 1 | 6.03 |
| CHEMBL226918 | — | — | 1 | 4.75 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.69 |
| CHEMBL226970 | — | — | 1 | 4.60 |
| CHEMBL223230 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL112668 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL226918 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 20280.0 | nM | 4.69 |
| CHEMBL226970 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL223230 | — | IC50 | = | 56000.0 | nM | 4.25 |