Compound Detail
CHEMBL226918
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Basic Information
| ChEMBL ID | CHEMBL226918 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOJCBMFUGXGTIJ-JZJYNLBNSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
332.4
MW (Da)
3.72
ALogP
4
HBA
1
HBD
37.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.68
IC50 1 meas. best 4.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.75 | 4.75 | 18000.0 | 1 |
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | EC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 18000.0 | nM | 4.75 | Inhibition of insulin release from rat INS-1E cells | 17425298 |
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 21000.0 | nM | 4.68 | Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repo... | 17425298 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17425298 | 10.1021/jm061440p | Sulfonylurea receptor 1, Kir6.2 | 2 |
| 17425298 | 10.1021/jm061440p | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine