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Assay Detail

CHEMBL914229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 infected MT4 cells by p24 core antigen ELISA in presence of 50% norman human serum
24
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V.
J Med Chem (2007) 50 : 2225 -2239
PubMed 17428043 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC95 23 - -
IC50 1 4.23 4.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437708 1 4.23
CHEMBL227497 1 -
CHEMBL426197 1 -
CHEMBL226971 1 -
CHEMBL389616 1 -
CHEMBL227575 1 -
CHEMBL223284 1 -
CHEMBL226917 1 -
CHEMBL387521 1 -
CHEMBL386515 1 -
CHEMBL216317 1 -
CHEMBL226667 1 -
CHEMBL216373 1 -
CHEMBL226765 1 -
CHEMBL226764 1 -
CHEMBL216683 1 -
CHEMBL227996 1 -
CHEMBL228023 1 -
CHEMBL227574 1 -
CHEMBL407451 1 -
CHEMBL224150 1 -
CHEMBL227550 1 -
CHEMBL390589 1 -
CHEMBL389503 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437708 IC50 = 59000.0 nM 4.23
CHEMBL227497 IC95 = 5830.0 nM -
CHEMBL426197 IC95 = 190.0 nM -
CHEMBL226971 IC95 = 1000.0 nM -
CHEMBL389616 IC95 = 1000.0 nM -
CHEMBL227575 IC95 = 1000.0 nM -
CHEMBL223284 IC95 = 1000.0 nM -
CHEMBL226917 IC95 = 1000.0 nM -
CHEMBL387521 IC95 = 500.0 nM -
CHEMBL386515 IC95 = 78.0 nM -
CHEMBL216317 IC95 = 500.0 nM -
CHEMBL226667 IC95 > 10000.0 nM -
CHEMBL216373 IC95 > 1000.0 nM -
CHEMBL226765 IC95 = 250.0 nM -
CHEMBL226764 IC95 = 620.0 nM -
CHEMBL216683 IC95 = 230.0 nM -
CHEMBL227996 IC95 = 620.0 nM -
CHEMBL228023 IC95 > 1000.0 nM -
CHEMBL227574 IC95 = 500.0 nM -
CHEMBL407451 IC95 = 400.0 nM -
CHEMBL224150 IC95 > 10000.0 nM -
CHEMBL227550 IC95 > 10000.0 nM -
CHEMBL390589 IC95 = 250.0 nM -
CHEMBL389503 IC95 = 120.0 nM -