Assay Detail
Functional
CHEMBL914270
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Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.57 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374683 | — | — | 1 | 8.80 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.80 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.80 |
| CHEMBL374257 | — | — | 1 | 8.77 |
| CHEMBL374481 | — | — | 1 | 8.72 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.20 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374683 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL374257 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL374481 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 20.0 | nM | 7.70 |