Assay Detail
Functional
CHEMBL914271
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Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.33 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.85 |
| CHEMBL374257 | — | — | 1 | 8.74 |
| CHEMBL374683 | — | — | 1 | 8.72 |
| CHEMBL374481 | — | — | 1 | 8.41 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.05 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.20 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL374257 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL374683 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL374481 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL107 | COLCHICINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL178 | DAUNORUBICIN | IC50 | > | 400.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 1000.0 | nM | - |