Assay Detail
Binding
CHEMBL914443
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Inhibition of mitogen-activated protein kinase p38 alpha
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.77 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374762 | — | — | 1 | 6.82 |
| CHEMBL222920 | — | — | 1 | 6.69 |
| CHEMBL426183 | — | — | 1 | 6.66 |
| CHEMBL373807 | — | — | 1 | 6.40 |
| CHEMBL376608 | — | — | 1 | 6.37 |
| CHEMBL221985 | — | — | 1 | 6.34 |
| CHEMBL10 | SB-203580 | — | 1 | 6.33 |
| CHEMBL221508 | — | — | 1 | 6.18 |
| CHEMBL374531 | — | — | 1 | 6.09 |
| CHEMBL222339 | — | — | 1 | 5.88 |
| CHEMBL221568 | — | — | 1 | 5.87 |
| CHEMBL223645 | — | — | 1 | 5.73 |
| CHEMBL389266 | — | — | 1 | 5.70 |
| CHEMBL387551 | — | — | 1 | 5.69 |
| CHEMBL373913 | — | — | 1 | 5.65 |
| CHEMBL222051 | — | — | 1 | 5.62 |
| CHEMBL373808 | — | — | 1 | 5.62 |
| CHEMBL225548 | — | — | 1 | 5.60 |
| CHEMBL225458 | — | — | 1 | 5.43 |
| CHEMBL374756 | — | — | 1 | 5.39 |
| CHEMBL225231 | — | — | 1 | 5.35 |
| CHEMBL225101 | — | — | 1 | 5.30 |
| CHEMBL387154 | — | — | 1 | 5.23 |
| CHEMBL376486 | — | — | 1 | 5.20 |
| CHEMBL222227 | — | — | 1 | 5.14 |
| CHEMBL427104 | — | — | 1 | 5.07 |
| CHEMBL225174 | — | — | 1 | 5.06 |
| CHEMBL374485 | — | — | 1 | 5.02 |
| CHEMBL224972 | — | — | 1 | - |
| CHEMBL388755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374762 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL222920 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL426183 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL373807 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL376608 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL221985 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL10 | SB-203580 | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL221508 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL374531 | — | IC50 | = | 813.0 | nM | 6.09 |
| CHEMBL222339 | — | IC50 | = | 1306.0 | nM | 5.88 |
| CHEMBL221568 | — | IC50 | = | 1343.0 | nM | 5.87 |
| CHEMBL223645 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL389266 | — | IC50 | = | 2001.0 | nM | 5.70 |
| CHEMBL387551 | — | IC50 | = | 2029.0 | nM | 5.69 |
| CHEMBL373913 | — | IC50 | = | 2236.0 | nM | 5.65 |
| CHEMBL222051 | — | IC50 | = | 2377.0 | nM | 5.62 |
| CHEMBL373808 | — | IC50 | = | 2409.0 | nM | 5.62 |
| CHEMBL225548 | — | IC50 | = | 2512.0 | nM | 5.60 |
| CHEMBL225458 | — | IC50 | = | 3732.0 | nM | 5.43 |
| CHEMBL374756 | — | IC50 | = | 4099.0 | nM | 5.39 |
| CHEMBL225231 | — | IC50 | = | 4435.0 | nM | 5.35 |
| CHEMBL225101 | — | IC50 | = | 4974.0 | nM | 5.30 |
| CHEMBL387154 | — | IC50 | = | 5849.0 | nM | 5.23 |
| CHEMBL376486 | — | IC50 | = | 6279.0 | nM | 5.20 |
| CHEMBL222227 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL427104 | — | IC50 | = | 8479.0 | nM | 5.07 |
| CHEMBL225174 | — | IC50 | = | 8692.0 | nM | 5.06 |
| CHEMBL374485 | — | IC50 | = | 9501.0 | nM | 5.02 |
| CHEMBL224972 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374530 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL387358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL443839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL221825 | — | IC50 | > | 10000.0 | nM | - |