Assay Detail
Binding
CHEMBL914526
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Inhibition of AchE in bovine erythrocytes
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.36 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225567 | — | — | 1 | 10.70 |
| CHEMBL225198 | — | — | 1 | 10.22 |
| CHEMBL223443 | — | — | 1 | 9.70 |
| CHEMBL225021 | — | — | 1 | 9.52 |
| CHEMBL389192 | — | — | 1 | 9.30 |
| CHEMBL427082 | — | — | 1 | 9.30 |
| CHEMBL225326 | — | — | 1 | 9.22 |
| CHEMBL225327 | — | — | 1 | 9.15 |
| CHEMBL223170 | — | — | 1 | 9.15 |
| CHEMBL223277 | — | — | 1 | 8.82 |
| CHEMBL388551 | — | — | 1 | 8.54 |
| CHEMBL225077 | — | — | 1 | 8.52 |
| CHEMBL224335 | — | — | 1 | 8.40 |
| CHEMBL223549 | — | — | 1 | 8.36 |
| CHEMBL426015 | — | — | 1 | 7.96 |
| CHEMBL224202 | — | — | 1 | 7.75 |
| CHEMBL224051 | — | — | 1 | 7.66 |
| CHEMBL224998 | — | — | 1 | 7.48 |
| CHEMBL388627 | — | — | 1 | 7.44 |
| CHEMBL223714 | — | — | 1 | 7.34 |
| CHEMBL224158 | — | — | 1 | 7.16 |
| CHEMBL388615 | — | — | 1 | 7.02 |
| CHEMBL224336 | — | — | 1 | 6.83 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.78 |
| CHEMBL388575 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225567 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL225198 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL223443 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL225021 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL389192 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL427082 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL225326 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL225327 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL223170 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL223277 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL388551 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL225077 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL224335 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL223549 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL426015 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL224202 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL224051 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL224998 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL388627 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL223714 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL224158 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL388615 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL224336 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL95 | TACRINE | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL388575 | — | IC50 | = | 180.0 | nM | 6.75 |