Assay Detail
Binding
CHEMBL914527
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Inhibition of human serum BChE
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.02 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224336 | — | — | 1 | 10.52 |
| CHEMBL225198 | — | — | 1 | 10.00 |
| CHEMBL224158 | — | — | 1 | 9.00 |
| CHEMBL224998 | — | — | 1 | 8.77 |
| CHEMBL225326 | — | — | 1 | 8.77 |
| CHEMBL225567 | — | — | 1 | 8.54 |
| CHEMBL225021 | — | — | 1 | 8.49 |
| CHEMBL427082 | — | — | 1 | 8.25 |
| CHEMBL389192 | — | — | 1 | 8.24 |
| CHEMBL223549 | — | — | 1 | 8.02 |
| CHEMBL388575 | — | — | 1 | 8.02 |
| CHEMBL223443 | — | — | 1 | 7.93 |
| CHEMBL223170 | — | — | 1 | 7.93 |
| CHEMBL224335 | — | — | 1 | 7.80 |
| CHEMBL388627 | — | — | 1 | 7.72 |
| CHEMBL388551 | — | — | 1 | 7.67 |
| CHEMBL223714 | — | — | 1 | 7.65 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.62 |
| CHEMBL224051 | — | — | 1 | 7.27 |
| CHEMBL225077 | — | — | 1 | 7.23 |
| CHEMBL225327 | — | — | 1 | 7.22 |
| CHEMBL224202 | — | — | 1 | 7.11 |
| CHEMBL388615 | — | — | 1 | 7.10 |
| CHEMBL223277 | — | — | 1 | 6.87 |
| CHEMBL426015 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224336 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL225198 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL224158 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL224998 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL225326 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL225567 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL225021 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL427082 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL389192 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL223549 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL388575 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL223443 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL223170 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL224335 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL388627 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL388551 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL223714 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL95 | TACRINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL224051 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL225077 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL225327 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL224202 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL388615 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL223277 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL426015 | — | IC50 | = | 206.0 | nM | 6.69 |