Assay Detail
Binding
CHEMBL914529
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Inhibition of human brain AchE
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 10.06 | 10.70 |
| Ki | 5 | 10.79 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225567 | — | — | 2 | 10.85 |
| CHEMBL223443 | — | — | 2 | 10.82 |
| CHEMBL225198 | — | — | 2 | 10.70 |
| CHEMBL225326 | — | — | 2 | 10.70 |
| CHEMBL225021 | — | — | 2 | 9.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225567 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL223443 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL225198 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL225326 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL225567 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL223443 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL225021 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL225326 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL225198 | — | Ki | = | 0.009 | nM | - |
| CHEMBL225021 | — | Ki | = | 0.0017 | nM | - |