Assay Detail
Functional
CHEMBL914532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE-induced beta amyloid peptide(1-40) aggregation by thioflavin T-based fluorometric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.25 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225567 | — | — | 1 | 5.70 |
| CHEMBL225021 | — | — | 1 | 5.70 |
| CHEMBL225198 | — | — | 1 | 5.22 |
| CHEMBL223443 | — | — | 1 | 5.16 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.89 |
| CHEMBL225326 | — | — | 1 | 4.82 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL60745 | EDROPHONIUM BROMIDE | — | 1 | - |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225567 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL225021 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL225198 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL223443 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL225326 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL95 | TACRINE | IC50 | - | — | - | |
| CHEMBL1190 | DECAMETHONIUM | IC50 | - | — | - | |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - | |
| CHEMBL60745 | EDROPHONIUM BROMIDE | IC50 | - | — | - | |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | - | — | - |