Assay Detail

CHEMBL914536

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Functional

Induction of DNA fragmentation in human HL60 cells after 16 hrs

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

Open DB target context

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

Selassie CD, Kapur S, Verma RP, Rosario M.
J Med Chem (2005) 48 : 7234 -7242
PubMed 16279782 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.68	5.86

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4296740	BUTYLATED HYDROXYANISOLE	-1.0	1	5.86
CHEMBL146	BUTYLATED HYDROXYTOLUENE	2.0	1	5.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4296740	BUTYLATED HYDROXYANISOLE	IC50	=	1380.0	nM	5.86
CHEMBL146	BUTYLATED HYDROXYTOLUENE	IC50	=	3180.0	nM	5.50