Assay Detail
ADMET
CHEMBL914964
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Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.27 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225562 | — | — | 1 | 4.43 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.43 |
| CHEMBL376338 | — | — | 1 | 4.42 |
| CHEMBL225369 | METHYL PAPYRIFERATE | — | 1 | 4.30 |
| CHEMBL224050 | PAPYRIFERIC ACID | — | 1 | 4.28 |
| CHEMBL224087 | — | — | 1 | 4.27 |
| CHEMBL224431 | — | — | 1 | 4.25 |
| CHEMBL388788 | — | — | 1 | 4.24 |
| CHEMBL225565 | — | — | 1 | 4.24 |
| CHEMBL224814 | — | — | 1 | 4.23 |
| CHEMBL375698 | — | — | 1 | 4.17 |
| CHEMBL387861 | METHYL SHOREATE | — | 1 | 4.17 |
| CHEMBL374628 | HYDROXYHOPANONE | — | 1 | 4.11 |
| CHEMBL224481 | CABRALEONE | — | 1 | - |
| CHEMBL224139 | OCOTILLONE | — | 1 | - |
| CHEMBL225315 | CABRALELACTONE | — | 1 | - |
| CHEMBL224197 | CABRALEAHYDROXYLACTONE | — | 1 | - |
| CHEMBL225604 | — | — | 1 | - |
| CHEMBL224816 | DIPTEROCARPOL | — | 1 | - |
| CHEMBL375731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225562 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL376338 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL225369 | METHYL PAPYRIFERATE | IC50 | = | 49600.0 | nM | 4.30 |
| CHEMBL224050 | PAPYRIFERIC ACID | IC50 | = | 52200.0 | nM | 4.28 |
| CHEMBL224087 | — | IC50 | = | 54200.0 | nM | 4.27 |
| CHEMBL224431 | — | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL388788 | — | IC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL225565 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL224814 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL375698 | — | IC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL387861 | METHYL SHOREATE | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL374628 | HYDROXYHOPANONE | IC50 | = | 77100.0 | nM | 4.11 |
| CHEMBL224481 | CABRALEONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL224139 | OCOTILLONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL225315 | CABRALELACTONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL224197 | CABRALEAHYDROXYLACTONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL225604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL224816 | DIPTEROCARPOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL375731 | — | IC50 | > | 100000.0 | nM | - |