Assay Detail
Functional
CHEMBL915281
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Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.35 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269306 | CDDO-CN | — | 1 | 9.00 |
| CHEMBL1720855 | — | — | 1 | 9.00 |
| CHEMBL223924 | — | — | 1 | 9.00 |
| CHEMBL224752 | — | — | 1 | 9.00 |
| CHEMBL376887 | — | — | 1 | 8.70 |
| CHEMBL223710 | — | — | 1 | 8.52 |
| CHEMBL558972 | — | — | 1 | 8.52 |
| CHEMBL222861 | — | — | 1 | 8.52 |
| CHEMBL376599 | — | — | 1 | 8.40 |
| CHEMBL221714 | — | — | 1 | 8.30 |
| CHEMBL225333 | — | — | 1 | 8.00 |
| CHEMBL223760 | — | — | 1 | 8.00 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.70 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 7.70 |
| CHEMBL222528 | — | — | 1 | 7.70 |
| CHEMBL356121 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269306 | CDDO-CN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1720855 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223924 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL224752 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL376887 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL223710 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL558972 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL222861 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL376599 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL221714 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL225333 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL223760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL222528 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL356121 | — | IC50 | = | 30.0 | nM | 7.52 |