Compound Detail
CHEMBL558972
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C#C[C@]12C=C(C#N)C(=O)C=C1[C@@]1(C)C=C(C#N)C(=O)C(C)(C)[C@@H]1CC2.Cl
Basic Information
| ChEMBL ID | CHEMBL558972 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GISBUMFQGHXHRX-GQRDWQEESA-N |
| Parent Compound | CHEMBL224752 |
| Active Moiety | CHEMBL224752 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
330.4
MW (Da)
3.04
ALogP
4
HBA
0
HBD
81.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW CHEMBL614631 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW | IC50 | = | 3.0 | nM | 8.52 | Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after... | 17367124 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17367124 | 10.1021/jm070141c | RAW | 1 |
Data from ChEMBL 36 via Core Engine