Assay Detail
Binding
CHEMBL915407
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Displacement of [3H]granisetron from 5HT3 receptor in Wistar rat cerebral cortex synaptosomal membranes
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.59 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085040 | — | — | 1 | 8.14 |
| CHEMBL3085041 | — | — | 1 | 7.25 |
| CHEMBL3085049 | — | — | 1 | 7.17 |
| CHEMBL3085048 | — | — | 1 | 7.15 |
| CHEMBL3085045 | — | — | 1 | 6.74 |
| CHEMBL3085052 | — | — | 1 | 6.64 |
| CHEMBL3085053 | — | — | 1 | 6.58 |
| CHEMBL1947052 | — | — | 2 | 6.53 |
| CHEMBL3085055 | — | — | 1 | 6.24 |
| CHEMBL3085054 | — | — | 1 | 6.16 |
| CHEMBL3085042 | — | — | 1 | 6.14 |
| CHEMBL1947049 | — | — | 2 | 6.00 |
| CHEMBL3085046 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085040 | — | IC50 | = | 7.178 | nM | 8.14 |
| CHEMBL3085041 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL3085049 | — | IC50 | = | 67.92 | nM | 7.17 |
| CHEMBL3085048 | — | IC50 | = | 70.96 | nM | 7.15 |
| CHEMBL3085045 | — | IC50 | = | 182.39 | nM | 6.74 |
| CHEMBL3085052 | — | IC50 | = | 230.67 | nM | 6.64 |
| CHEMBL3085053 | — | IC50 | = | 262.42 | nM | 6.58 |
| CHEMBL1947052 | — | IC50 | = | 298.54 | nM | 6.53 |
| CHEMBL1947052 | — | IC50 | = | 498.88 | nM | 6.30 |
| CHEMBL3085055 | — | IC50 | = | 576.77 | nM | 6.24 |
| CHEMBL3085054 | — | IC50 | = | 691.83 | nM | 6.16 |
| CHEMBL3085042 | — | IC50 | = | 716.14 | nM | 6.14 |
| CHEMBL1947049 | — | IC50 | = | 1004.62 | nM | 6.00 |
| CHEMBL3085046 | — | IC50 | = | 1051.96 | nM | 5.98 |
| CHEMBL1947049 | — | IC50 | = | 1563.15 | nM | 5.81 |