Assay Detail
Functional
CHEMBL915546
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Inhibition of NF-kappaB activation in LPS-stimulated RAW264.7 cells after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-kappaB activation and NO production in macrophage RAW264.7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.16 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389954 | INFLEXIN | — | 1 | 6.64 |
| CHEMBL225488 | INFLEXARABDONIN G | — | 1 | 6.62 |
| CHEMBL389487 | EXCISUSIN B | — | 1 | 6.58 |
| CHEMBL225489 | INFLEXANIN A | — | 1 | 6.40 |
| CHEMBL225258 | INFLEXINOL | — | 1 | 6.36 |
| CHEMBL223544 | EXCISUSIN A | — | 1 | 6.05 |
| CHEMBL376605 | EXCISUSIN E | — | 1 | 5.99 |
| CHEMBL224372 | INFLEXARABDONIN I | — | 1 | 5.94 |
| CHEMBL4298697 | — | — | 1 | 5.94 |
| CHEMBL427086 | INFLEXANIN B | — | 1 | 5.74 |
| CHEMBL388127 | EXCISUSIN D | — | 1 | 5.49 |
| CHEMBL224140 | INFLEXARABDONIN A | — | 1 | - |
| CHEMBL390108 | EXCISUSIN C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389954 | INFLEXIN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL225488 | INFLEXARABDONIN G | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL389487 | EXCISUSIN B | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL225489 | INFLEXANIN A | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL225258 | INFLEXINOL | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL223544 | EXCISUSIN A | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL376605 | EXCISUSIN E | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL224372 | INFLEXARABDONIN I | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4298697 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL427086 | INFLEXANIN B | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL388127 | EXCISUSIN D | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL224140 | INFLEXARABDONIN A | IC50 | > | 10000.0 | nM | - |
| CHEMBL390108 | EXCISUSIN C | IC50 | > | 10000.0 | nM | - |